0034. Changes of TLR2, TLR4, MYD88 MRNA expressions on peripheral blood mononuclear cell in severe sepsis patients during treatment with thymosin α1
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چکیده
Results There was no statistical significance between 28 day mortality rate in the control group and that of thymosin group(35.7% vs 23.1%, P=0.310). TLR2, TLR4 and MyD88 mRNA expressions in the thymosin group were respectively increased on enrollment day, day 3 and day 7, however, this increasing trend was not found in the control group. On day 3, TLR2 and TLR4 mRNA expressions in the thymosin group were higher than those in the control group (2.31 ± 0.79 vs 1.83 ± 0.51, 7.31 ± 0.79 vs 6.55 ± 0.92, P < 0.05). On day 7, TLR2, TLR4 and MyD88 mRNA expressions in the thymosin group were higher than those in the control group (2.75 ± 1.17 vs 1.63 ± 0.36; 7.75 ± 1.03 vs 6.39 ± 0.72; 4.26 ± 0.77 vs 3.77 ± 0.68, P<0.05).
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